Where does Choline Come From?

The Complete Guide to Choline as a Nootropic Stack

We briefly covered this in our Top 10 Stacks to Improve Modafinil Performance article, and gradually we are delving deeper into each of those as we’re always getting more questions from our followers.

In the world of Nootropics, Choline is a true VIP. It is not only a vital nutrient and powerful brain booster, but it is also the supplement which helps other cognitive enhancers to bring out the best. Effective, Safe, and affordable, choline is a unique addition to every nootropic stack. In this complete guide, we will break down what choline is? , why it is significant for your Nootropic stack? , and which choline should help you choose?

An Introduction to Choline:

Choline is vital to both brain and body. It is an essential nutrient with the classification of vitamin B complex. Choline is important to keeping health at every age, and it is used to treat and avoid an astonishing variety of physical illnesses and disorders, including, hepatitis, asthma, and cancer.
However, for Nootropic consumers, choline is mainly famous because of its ability to enhance focus, memory and cognitive function, both alone with the combination of other supplements. A precursor to acetylcholine is choline. Acetylcholine is a neurotransmitter which strongly associated with learning, memory, and full cognitive function, and it is renowned as a brain booster in its own right. Choline also amplifies and enhances the effects of other Nootropics, and it is considered by many to be a significant component of every Nootropic stack. Mainly, It is useful in combination with the racetams, which are among the most prevalent and great smart drugs.

Choline is one of our favorites to be used with modafinil
Choline is one of our favorites to be used with modafinil

For well-informed nootropic users, the question is not whether to add choline; the problem is that “which choline source will serve those best?” This answer depends on many elements, including circumstances of use, personal preferences, and interaction of various choline sources with the other nootropics stack. If you want to choose the most excellent choline source, it is essential to understand as much as possible about starting choline with the basics,

What Is Choline?

Choline nutrient is an essential water-soluble that is crucial to equally brain and liver function in the human body. Choline is a chemical quaternary ammonium salt, which generally classified with the vitamin B complex. By definition, choline is a micro-nutrient rather than a vitamin. First, Choline isolated in 1862, but it was not classified as a necessary nutrient until 1998.
Choline has many functions in the body. Regarding cognitive enhancement and nootropics, it is the most significant function as a precursor of the neurotransmitter acetylcholine, which is vital to nerve communication and for brain functions related to memory, learning ability, concentration, and all cognitive functions. Your body breaks down choline from your diet into the neurotransmitter; this is the reason that having sufficient choline in your diet is healthy for your optimal brain performance.

Research reported that plenty amount of choline is crucial to human health at all age. The plenty of need for choline starts before birth because the fetal brain development is adversely affected when mothers do not get sufficient choline. Postnatal supplementation of choline ameliorates the effects of fetal alcohol syndrome, reduces the chance of brain disorders, and enhances learning.

In both adults and children, choline has been shown to suppress the inflammation and oxidative stress which associate with asthma. Suitable choline intake has been proven to stop and prevent liver disease. It is useful in the treatment and deterrence of brain disorders like cerebellar ataxia, schizophrenia, and Tourette’s, illness. The choline impact on healthy Adults can enhance the development of delay fatigue and lean muscle mass.
Choline becomes even more crucial as we age. It effectively helps to restore memory and other cognitive skills that may be diminished by age-related illnesses and conditions. Most notably, it has proved that choline improves minor to moderate Alzheimer’s dementia. The American Psychological Association marked choline as a nutrient that has substantial potential as a therapeutic agent in the treatment of depression, Parkinsonism, and memory disorders.

Where Does Choline Come From?

The body produces some choline in the liver, but not enough to meet the recommended daily adequate intake which is estimated to be 425-550 mg per day for adults. However, there are many dietary sources of choline, including beef, liver, eggs, navy beans, cauliflower, almonds, peanut butter, and tofu. It has estimated that about 90% of the population consumes an insufficient amount of choline.

Where does Choline Come From?
Where does Choline Come From?

In addition to dietary sources and original synthesis, choline is also available in the form of supplement. Choline supplements vary dramatically in quality and strength. Lecithin is the most common choline supplement, and it is also the weakest form of choline which may not boost cognitive abilities.

For Nootropic as mentioned before, the real reason we are concerned about the supplementation of choline is that we want to ensure that our brain has the optimum amount of neurotransmitter acetylcholine. From natural sources, choline can help with this, but a substitute option is acetylcholine precursors that are more effective in raising acetylcholine neurotransmitter levels such as, centrophenoxine, Alpha GPC, or CDP choline. All three are robust and reliable supplements that can increase your neurotransmitter levels with different interactions and strong points with other nootropics and will be cover in more detail below.

Why is Choline Important in Your Nootropic Stack?

If you are taking nootropics, you must consider adding choline to each stack. Moreover, if you are taking racetam class nootropics like oxiracetam, piracetam, aniracetam, or pramiracetam, additional choline is not a “should,” it is an absolute for getting the most exceptional results. Here is why. Racetams work in massive part by controlling the release of acetylcholine, the neurotransmitter most closely associated with cognition. Racetams do not create additional acetylcholine themselves, but they do rouse acetylcholine receptor sites, which in turn stimulates the production of this crucial neurotransmitter. Moreover, that is where the choline comes inside.

The precursor of acetylcholine is Choline, a critical building block that is essential to its production, the more acetylcholine produces, the more choline is available in the brain, and the more acetylcholine circulates through the neural pathways, the better the focus, memory, learning ability, concentration, and general cognitive abilities of the brain.
Choline has the properties of nootropic, but with the combination of racetam, it becomes a potent potentiator. The Racetam and Choline to have amplified effects, and studies have shown that when choline and racetams used together, the results are far superior to that of drug whether used alone.

Racetam class nootropics make a noteworthy draw on choline stores, so the available amount of supplemented choline for conversion is hugely recommended. Not only it is the only way to guarantee the best results from your nootropics, but also it is the most delicate way to avoid a minor and irritating headache that comes with the use of racetam.

Choline Source Comparison: Which One Is Best?

Once you have decided to make a choline supplement from the part of your nootropic stack, how do you know what to add? There is no clear-cut or simple answer, and what is right for one occasion or person may not be right for another.

Choline supplements vary considerably in each respect, from mechanisms of action to cost to potency. Each has its determining and positive effects, so adding to your nootropic stack is a matter of understanding that how they work, what they offer, and decide which is the best fit with your necessities and your nootropics.

Lecithin / Choline Bitartrate:

Choline Bitartrate
Choline Bitartrate

These are the cheapest and commonly available choline supplements found in most of the drug stores, big box retailers, and supermarkets. Unfortunately, they are also the least powerful and effective. However these supplements typically contain a high percentage weight of choline, the choline they provide appears to be less effective than that of CDP Choline, Alpha GPC or centrophenoxine. Choline/Lecithin bitartrate supplements seem to have almost the same effect as consuming nutritional choline; they can avoid deficiency, but provide little regarding nootropic benefit.


  • It is Cheap and readily available.


  • There is a minimal benefit of nootropic.
  • How is it different from other choline supplements?

It is a Good choice if you have a limited budget, and your primary concern is to prevent choline deficiency, not to achieve the benefits of Nootropic.

Typical dose: 500-2000 mg.

Alpha GPC:

Alpha GPC Is the Most Popular
Alpha GPC Is the Most Popular

It is a concentrated choline supplement which is useful, safe and fast-acting. It is incredibly bioavailable when taken orally and crosses the blood-brain barrier reliably and quickly. It directly delivers high-quality choline to the brain to convert into acetylcholine. Structurally composed of phosphate, choline, and glycerol. It metabolises into a combination of glycerol phosphate and choline on absorption. Structurally, Alpha GPC is 40% choline by weight, and it is in the form of primary choline storage or cholinergic.

Alpha GPC is most favoured with many nootropic consumers in massive part because not only it works rapidly and reliably in conjunction with the Racetams, but also it has many other benefits. One of the most excellent benefits of Alpha GPC is that it significantly boost mental energy and improve mood without creating restlessness or interference with sleep. It is also supposed to help overall brain health and may have anti-ageing advantages. It also stimulates the release of HGH (Human Growth Hormone) and can raise strength and decline recovery time after exertion.


  • It works quickly and consistently and produces results within an hour.
  • It has significant Nootropic benefits of its own, and it becomes mighty potent when combined with racetams.
  • It acts as a mental energy and mood booster, and it also helps to improve and strength memory after exertion.
  • It may have a preventative brain and anti-ageing health benefits and is generally well tolerated and safe.


  • By research, it has shown that there are some slight side effects, and it is known to interact unfavourably with Scopolamine which is used to treat short-tempered disease and other disorders.
  • It may not be readily available in stores.
    How is it different from other choline supplements?

It stimulates the release of HGH and makes it valuable for growing the development of lean muscle mass and decreasing recovery time after a workout.

Excellent choice if

  • You are interested in a fast-acting nootropic that works fit with racetams.
  • You would like to add an energy booster that does not interfere with normal sleep patterns.
  • You are interested in a supplement with anti-ageing benefits.
  • You are an active person or an athlete who is interested in increasing strength and reducing recovery time.
  • You are a student and preparing to study or anyone who is interested in enhancing mental energy, memory, and cognitive abilities in general.
    Typical dose: 300-600 mg

CDP Choline (Citicoline):

Citicoline another Popular Chiline Variant

CDP Choline is also known as cytidine-diphosphate or citicoline choline. It is a potent and highly stackable nootropic supplement which is well-known for its ability to increase energy, enhance memory and protect the brain against memory loss. It also increases mental power, improves focus and clarity of thought. Moreover, it may be useful for the treatment of stroke, head injuries, and neurodegenerative diseases.

CDP choline works rapidly and consistently, metabolising within an hour of consumption. CDP choline is structurally 18.5% choline by weight, but it is not classified chemically as a cholinergic. It metabolizes into cytidine and choline, which disperse quickly all over the body by crossing the brain-blood barrier and enter the central nervous system. The component of choline acts as a precursor to acetylcholine and the element of cytidine converts into uridine. Uridine is a nucleotide base that is significant to neural membrane production, and it believes in enhancing cognition. Furthermore, CDP choline rouses the sympathetic nervous system, and it can increase motivation and energy.


  • It has excellent bioavailability.
  • It is very tolerated even at high dosages
  • It is fast acting and reliable.
  • It is a potent nootropic and works synergistically with other nootropics, especially with the racetams.
  • It delivers an additional nootropic component (uridine/cytidine) that rises neural connections.


  • It is not cholinergic and must be metabolised to release choline.
  • Somewhat it is lower in choline by weight than Alpha GPC.
  • It has some minor side effects.
  • It may not be readily available in stores.
    How it is different from other choline supplements:
  • It stimulates the sympathetic nervous system, which escalates both mental and physical energy.
  • It brings another nootropic component that enhances neural synthesis.

Excellent choice if :

  • You are interested in a supplement that offers nootropic benefits and works perfectly with racetams.
  • You are a sportsman or active person who is interested in an excellent pre-workout supplement that increases drive and motivation.
  • You are a student who is preparing to study or anyone who is interested in enhancing mental energy, memory, and cognitive abilities.
  • You want a supplement with proven brain protectant and anti-ageing properties.

Typical dose: 250-750 mg


Centrophenoxine is not choline but has many similarities

Technically Centrophenoxine is not a source of choline, but it does have the ability to augment acetylcholine levels in the brain and making it have a strong pair with cholinergic nootropics while delivering a variety of other advantages as well. It is a proven memory booster which increases energy, enhances mood, and considered as an outstanding brain protectant and anti-ageing supplement. It is a synthetic version of DMAE and a fat-soluble compound of PCPA (parachlorphenoxyacetic). Due to its metabolization in the liver, it is cholinergic.

Centrophenoxine escalates the synthesis of acetylcholine, which makes it make a natural pairing with racetams or any other nootropics draw heavily on choline stores. It also acts as a brain booster by increasing the absorption of both glucose and oxygen, which in turn enhances general cognition, mood, and clarity of thought. Centrophenoxine acts as an effective antioxidant, due to which it flushes out waste material of brain cells and also break down the buildup of Lipofuscin, an age-related toxin that badly affects memory and cognition.


  • It is safe, reliable, and well-tolerated.
  • It is an anti-ageing supplement.
  • It increases complete brain activity and improves both nutrient and oxygen absorption.
  • It increases both mental and physical energy.
  • It has nootropic properties and works perfectly with racetams. Moreover, it supplies the additional choline they require


  • It could potentially interfere with common sleep patterns(if taken late in the day)
  • It has some minor side effects.
  • It may not be readily available in stores.
  • How it’s different from other choline supplements?
  • It is fat-soluble and metabolised in the liver.
  • It significantly increases complete brain functions by increasing nutrient and oxygen absorption.
  • It is a potent anti-ageing compound that can stop or reverse age-related cellular damage in the brain.

Excellent choice if:

  • You are stacking it with racetams or other nootropics which are choline-dependent.
  • You are a student and preparing to study or anyone who is interested in significantly improving focus, memory, fluid intelligence, or clarity of thought.
  • You are interested in increasing both mental and physical energy.
  • You want a supplement with serious anti-ageing benefits.

Typical dose: 250 mg

Choline Safety:

Generally, choline is very well-tolerated and safe, and most consumers report no side effects when using choline in prescribed amounts. There are some side effects at very high dosages which includes, headaches, low blood pressure, nausea, gastrointestinal distress, vomiting, and diarrhea. However, reducing the dosage eliminates any unwanted side effects.

Final Remarks:

Choline is a vital supplement for anyone who is serious about enhancing their cognitive abilities. CDP choline, Alpha GPC, and centrophenoxine are all excellent nootropic choline supplements that work tremendously well and shine in combination with other nootropics, particularly with racetams. Any of them is an excellent addition to a stack and will quickly and reliably deliver the additional amount of choline, the racetams require, so choosing among them is less a matter of “which is Best,” but more a question of “which one suits my current needs best.”

We will be selling Choline at some point this year; we are trying different ones with different nootropics with various customers to try and decide the best way to go about selling them.

Subscribe to us for up to date news on when our products are ready and if you have any questions, please Contact Us.

Complete Guide to Choline as a Nootropic Stack
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Complete Guide to Choline as a Nootropic Stack
Choline is a true VIP. It is not only a vital nutrient and powerful brain booster, but it is also the supplement which helps other cognitive enhancers.
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Dr Modafinil
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One thought on “The Complete Guide to Choline as a Nootropic Stack

  1. Great read and really informative, for ages I have been buying CHoline Bitarte and thinking it is the only one. Really looking forward to trying these other ones and I will let you know my findings! I have been taking Choline Birate powder for many years every day so I will have a good idea as to how your recommendations compare. Will keep you in the loop over the next week or two!!

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